Leases - Additional Information (Details)	1 Months Ended	3 Months Ended
	Nov. 30, 2021 USD ($) Contract	Mar. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Lessee Lease Description [Line Items]
Right-of-use assets		$ 74,828,000	$ 31,945,000
Liabilities under lease		76,481,000
Watertown Lease
Lessee Lease Description [Line Items]
Tenant improvements	$ 2,600,000	0
Tenant improvement allowance expected to be received		$ 2,600,000
Watertown Lease | Office and Laboratory Space
Lessee Lease Description [Line Items]
Lessee operating lease, description		In July 2017, the Company entered into a lease of office and laboratory space for its headquarters at 490 Arsenal Way, Suite 200 in Watertown, Massachusetts, or the Watertown Lease.
Watertown Lease | Newly Leased Space
Lessee Lease Description [Line Items]
Amended lease commencement date	2022-01
Amended lease, rent payment commencement date	2022-03
Amended lease termination date	2032-03
Lease term of amended lease terminate period	10 years
Tenant improvements	$ 2,600,000
Extend lease term of amended lease period	5 years
Restricted cash		$ 3,300,000
Number of amended lease separate contracts | Contract	2
Right-of-use assets	$ 44,400,000
Liabilities under lease	$ 44,100,000