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Stock-based Compensation - Additional Information (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 30, 2021
Mar. 03, 2020
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Feb. 28, 2022
Jan. 31, 2022
Jan. 01, 2022
Oct. 31, 2020
Sep. 30, 2020
Dec. 28, 2015
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Stock-based compensation, common stock shares authorized     150,000,000 150,000,000         150,000,000    
Payments for repurchase of common stock   $ 100   $ 194 $ 30            
Payments for relinquishment of right to purchase common stock upon exercise of stock options   $ 700                  
Stock-based compensation, common stock shares outstanding     48,688,875 43,059,632              
Restricted Stock Units                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Stock-based compensation, options vesting description     Vesting of the RSUs are contingent upon the determination of achievement of certain discovery and clinical milestones, or as specified market conditions are met.                
Share-based compensation, number of common stock issuable per RSU vested     1                
Subsequent Event | Restricted Stock Units                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Stock-based compensation, shares authorized for issuance           563,500 563,500        
2015 Incentive Stock Option and Grant Plan                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Stock-based compensation, common stock shares reserved for issuance     9,704,418               2,525,327
Stock-based compensation, options vesting description     Options granted under the 2015 Plan generally vest over a period of five or eight years with a cliff vesting at one year and quarterly vesting thereafter and options that lapse or are forfeited are available to be granted again.                
Contractual life of options from the date of grant     10 years                
Stock-based compensation, common stock shares available for issuance     3,720,993                
2015 Incentive Stock Option and Grant Plan | Minimum                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Stock-based compensation, options vesting period     5 years                
2015 Incentive Stock Option and Grant Plan | Maximum                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Stock-based compensation, options vesting period     8 years                
2020 Stock Option and Incentive Plan                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Stock-based compensation, common stock shares reserved for issuance     9,704,418             6,567,144  
Stock-based compensation, common stock shares available for issuance     3,720,993                
Percentage of outstanding shares of common stock 5.00%                    
Unrecognized compensation costs     $ 74,500                
Expected to be recognized over a weighted average period     2 years 10 months 24 days                
2020 Stock Option and Incentive Plan | Subsequent Event                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Stock-based compensation, common stock shares authorized               2,434,443      
2020 Employee Stock Purchase Plan                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Stock-based compensation, common stock shares reserved for issuance     861,765                
Percentage of outstanding shares of common stock 1.00%                    
Maximum authorized payroll deduction percentage of eligible compensation for eligible employees     15.00%                
Shares issued under employee stock purchase plan     6,640                
Stock-based compensation, common stock shares outstanding 656,714                    
2020 Employee Stock Purchase Plan | Subsequent Event                      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                      
Stock-based compensation, common stock shares authorized               486,888