X0206 3 2022-03-16 0 0001662579 C4 Therapeutics, Inc. CCCC 0001797388 Schick Kelly C/O C4 THERAPEUTICS, INC. 490 ARSENAL WAY #200 WATERTOWN MA 02472 0 1 0 0 Chief People Officer Stock Option (Right to Buy) 37.46 2031-01-10 Common Stock 92000 D Stock Option (Right to Buy) 22.71 2032-02-13 Common Stock 78500 D Performance Restricted Stock Units 2025-02-28 Common Stock 26250 D 25% of the shares underlying this option vested and became exercisable on January 11, 2022, with the remainder vesting in twelve equal quarterly installments thereafter. The shares underlying this option shall vest and become exercisable in sixteen equal quarterly installments following the grant date, with the first installment vesting on May 14, 2022. Each performance restricted stock unit ("PRSU") represents the contingent right to receive one share of the Issuer's Common Stock upon vesting and settlement. 4,500 PRSUs shall vest upon satisfaction of three escalating share price vesting milestones, and the remaining 21,750 PRSUs shall vest upon satisfaction of certain discovery and clinical milestones. Exhibit 24 - Power of Attorney /s/ Jolie M. Siegel, Attorney-in-Fact 2022-03-17