SCHEDULE 13G/A 0000814133 XXXXXXXX LIVE 4 Common Stock 04/30/2025 0001662579 C4 Therapeutics, Inc. 12529R107 490 ARSENAL WAY SUITE 120 WATERTOWN MA 02472 Rule 13d-1(b) WASATCH ADVISORS LP a 6754534.00 0.00 7473332.00 0.00 7473332.00 10.5 IA C4 Therapeutics, Inc. 490 ARSENAL WAY, SUITE 120, WATERTOWN, MASSACHUSETTS, 02472 Wasatch Advisors LP 505 Wakara Way, 3rd Floor, Salt Lake City, 84108, United States Delaware N IA 7,473,332 10.5% 6,754,534 0 7,473,332 0 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. WASATCH ADVISORS LP Mike Yeates 05/07/2025