CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 129,329	$ 86,454
Short-term investments	123,362	166,155
Accounts receivable	10,653	4,597
Receivable from Ionis Pharmaceuticals, Inc.	647
Inventories	8,641	85
Other current assets	5,809	9,944
Total current assets	278,441	267,235
Property, plant and equipment, net	5,277	5,696
Operating lease right-of-use assets	11,300
Intangible assets, net	84,529	88,914
Deposits and other assets	3,620	3,416
Total assets	383,167	365,261
Current liabilities:
Accounts payable	5,711	12,068
Payable to Ionis Pharmaceuticals, Inc.		18,901
Accrued compensation	9,382	8,583
Accrued liabilities	15,211	14,787
Current portion of deferred revenue	10,840	25,354
Other current liabilities	1,977	968
Total current liabilities	43,121	80,661
Long-term portion of lease liabilities	14,558	4,442
Long-term portion of deferred revenue		3,434
Total liabilities	57,679	88,537
Stockholders’ equity:
Common stock, $0.001 par value; 125,000,000 shares authorized at September 30, 2019 and December 31, 2018; 93,885,414 and 89,345,978 shares issued and outstanding at September 30, 2019 and December 31, 2018, respectively.	94	89
Additional paid-in capital	889,133	799,001
Accumulated other comprehensive loss	(63)	(324)
Accumulated deficit	(563,676)	(522,042)
Total stockholders’ equity	325,488	276,724
Total liabilities and stockholders’ equity	$ 383,167	$ 365,261