X0306 4 2020-09-22 0 0001662524 AKCEA THERAPEUTICS, INC. AKCA 0001791857 Jenne Kyle C/O AKCEA THERAPEUTICS, INC. 22 BOSTON WHARF ROAD, 9TH FLOOR BOSTON MA 02210 0 1 0 0 Chief Commercial Officer Common Stock 2020-09-22 4 S 0 720 18.12 D 52012 D Sale of shares of common stock to cover tax withholding obligations associated with the vesting of a Restricted Stock Unit Award granted to the Reporting Person on September 19, 2019. /s/ Joshua F. Patterson, Attorney-in-Fact 2020-09-24