<SEC-DOCUMENT>0001193125-20-259719-index.html : 20200930
<SEC-HEADER>0001193125-20-259719.hdr.sgml : 20200930
<ACCEPTANCE-DATETIME>20200930164330
ACCESSION NUMBER:		0001193125-20-259719
CONFORMED SUBMISSION TYPE:	SC TO-T/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20200930
DATE AS OF CHANGE:		20200930
GROUP MEMBERS:		AVALANCHE MERGER SUB, INC.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AKCEA THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001662524
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				472608175
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC TO-T/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90051
		FILM NUMBER:		201212749

	BUSINESS ADDRESS:	
		STREET 1:		22 BOSTON WHARF RD
		STREET 2:		9TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		617-207-0202

	MAIL ADDRESS:	
		STREET 1:		22 BOSTON WHARF RD
		STREET 2:		9TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC TO-T/A

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC TO-T/A
<SEQUENCE>1
<FILENAME>d43083dsctota.htm
<DESCRIPTION>SC TO-T/A
<TEXT>
Document 1 - file: d43083dsctota.htm

</DOCUMENT>
</SEC-DOCUMENT>