SCHEDULE 14C INFORMATION

Information Statement Pursuant to Section 14(c) of the Securities Exchange Act of 1934

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☐ Preliminary Information Statement

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☐ Definitive Information Statement

☒ Definitive Additional Materials

Akcea Therapeutics, Inc.

(Name of Registrant as Specified In Its Charter)

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Important Notice Regarding the Availability of Materials

for the Annual Meeting of Stockholders to be held on June 14, 2019

	Meeting Information
AKCEA THERAPEUTICS, INC.	Meeting Type:           Annual Meeting
	For holders as of:     April 17, 2019
	Date:    June 14, 2019     Time:  2:00 PM EDT
	Location:   Meeting live via the Internet-please visit www.virtualshareholdermeeting.com/AKCA2019.
	The company will be hosting the meeting live via the Internet this year. To attend the meeting via the Internet please visit www.virtualshareholdermeeting.com/AKCA2019 and be sure to have the information that is printed in the box marked by the arrow (located on the following page).

AKCEA THERAPEUTICS, INC. 22 BOSTON WHARF ROAD, 9TH FLOOR BOSTON, MA 02210	You are receiving this communication because you hold securities in the company listed above. They have released informational materials that are now available for your review. This notice provides instructions on how to access AKCEA THERAPEUTICS, INC. materials for informational purposes only. We are not asking you for a proxy and you are requested not to send us a proxy.
	You may view the materials online at www.materialnotice.com and easily request a paper or e-mail copy (see reverse side).

See the reverse side for instructions on how to access materials.

——  How to Access the Materials  ——

	Materials Available to VIEW or RECEIVE:
	INFORMATION STATEMENT
	How to View Online:
	Have the information that is printed in the box marked by the arrow (located on the following page) and visit: www.materialnotice.com.
	How to Request and Receive a PAPER or E-MAIL Copy:
	If you want to receive a paper or e-mail copy of these materials, you must request one. There is NO charge for requesting a copy. Please choose one of the following methods to make your request:
	1) BY INTERNET:	www.materialnotice.com
	2) BY TELEPHONE:	1-800-579-1639
	3) BY E-MAIL*:	sendmaterial@materialnotice.com
	* If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked by the arrow (located on the following page) in the subject line.
	Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment advisor.

	YOU ARE CORDIALLY INVITED TO ATTEND THE ANNUAL MEETING OF STOCKHOLDES OF AKCEA THERAPEUTICS, INC. (THE “COMPANY”) TO BE HELD VIA A VIRTUAL SHAREHOLDER MEETING ON FRIDAY, JUNE 14, 2019 AT 2:00 PM EDT. PLEASE USE THE FOLLOWING URL TO ACCESS THE MEETING (WWW.VIRTUALSHAREHOLDERMEETING.COM/AKCA2019).
	WE ARE NOT ASKING YOU FOR A PROXY AND YOU ARE REQUESTED NOT TO SEND US A PROXY.

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