License Agreements and Services Agreement with Ionis (Tables)

6 Months Ended

Jun. 30, 2018

License Agreements and Services Agreement with Ionis [Abstract]

Operating Expenses Generated by Transactions with Ionis

The following table summarizes the amounts included in our operating expenses and amounts related to the TTR licensing agreement that were generated by transactions with Ionis for the following periods (in thousands):

	Three Months Ended June 30,						Six Months Ended June 30,
	2018			2017			2018			2017
Services performed by Ionis	$	6,045		$	2,998		$	7,990		$	5,955
Active pharmaceutical ingredient manufactured by Ionis		—			2,930			5,229			6,013
Commercial inventory manufactured by Ionis		5,996			—			5,996			—
Sublicensing expenses		—			—			—			48,394
Out-of-pocket expenses paid by Ionis		16,029			5,316			23,016			17,189
Total charges generated by transactions with Ionis		28,070			11,244			42,231			77,551
Payable balance to Ionis at the beginning of the period		27,737			15,000		$	14,365			24,355
Less: total amounts paid to Ionis during the period		(27,737	)		(15,000	)		(28,526	)		(57,268	)
Less: receivable from Ionis		(933	)		—			(933	)		—
Less: non-cash sublicensing expenses		—			—			—			(33,394	)
Total amount payable to Ionis at period end	$	27,137		$	11,244		$	27,137		$	11,244