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Strategic Collaboration with Novartis (Details)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Jul. 31, 2017
USD ($)
Jun. 30, 2017
USD ($)
Mar. 31, 2017
USD ($)
Drug
Jun. 30, 2016
USD ($)
Jun. 30, 2017
USD ($)
Jun. 30, 2016
USD ($)
Strategic Collaboration with Novartis [Abstract]            
Revenue earned   $ 14,128   $ 0 $ 23,725 $ 0
Novartis [Member]            
Strategic Collaboration with Novartis [Abstract]            
Number of drugs with exclusive option that could be exercised | Drug     1      
Upfront payment received     $ 75,000      
Portion of upfront payment retained     60,000      
Portion of upfront payment paid as sublicense fee to Ionis     $ 15,000      
License fee receivable per drug   150,000     150,000  
Next prospective milestone   25,000     $ 25,000  
Percentage of license fees, milestone payments and royalties paid as sublicense fee to Ionis         50.00%  
Revenue earned   $ 14,100     $ 23,700  
Concentration percentage   100.00%     100.00%  
Deferred revenue   $ 84,700     $ 84,700  
Novartis [Member] | Subsequent Event [Member]            
Strategic Collaboration with Novartis [Abstract]            
Proceeds from sale of common stock $ 50,000          
Novartis [Member] | AKCEA-APO(a)-L [Member]            
Strategic Collaboration with Novartis [Abstract]            
Maximum amount of payments receivable for milestones   600,000     600,000  
Maximum amount of payments receivable for development milestones   25,000     25,000  
Maximum amount of payments receivable for regulatory milestones   290,000     290,000  
Maximum amount of payments receivable for commercialization milestones   285,000     $ 285,000  
Royalty percentage received on sales of drug         20.00%  
Novartis [Member] | AKCEA-APOCIII-L [Member]            
Strategic Collaboration with Novartis [Abstract]            
Maximum amount of payments receivable for milestones   530,000     $ 530,000  
Maximum amount of payments receivable for development milestones   25,000     25,000  
Maximum amount of payments receivable for regulatory milestones   240,000     240,000  
Maximum amount of payments receivable for commercialization milestones   $ 265,000     $ 265,000  
Royalty percentage received on sales of drug         20.00%