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Line of Credit Agreement with Ionis (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jul. 19, 2017
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Jan. 31, 2017
Dec. 31, 2016
Line of Credit Agreement with Ionis [Abstract]              
Outstanding balance, including principal and interest   $ 107,507   $ 107,507     $ 0
Interest expense   965 $ 0 1,507 $ 0    
Subsequent Event [Member]              
Line of Credit Agreement with Ionis [Abstract]              
Shares issued upon conversion of line of credit (in shares) 13,438,339            
Ionis [Member] | Line of Credit [Member]              
Line of Credit Agreement with Ionis [Abstract]              
Maximum borrowing capacity           $ 150,000  
Outstanding balance   $ 106,000   $ 106,000      
Interest rate   4.00%   4.00%      
Outstanding balance, including principal and interest   $ 107,500   $ 107,500      
Interest expense   $ 965   $ 1,507