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Significant Accounting Policies, Revenue Recognition (Details)
shares in Millions, $ in Millions
1 Months Ended 3 Months Ended 6 Months Ended
Jul. 31, 2017
USD ($)
Mar. 31, 2017
USD ($)
Agreement
Drug
shares
Jun. 30, 2017
USD ($)
AccountingUnit
Category
Stage
Revenue Recognition [Abstract]      
Number of categories of milestone events | Category     3
Number of stages in life-cycle of drugs | Stage     3
Minimum [Member]      
Revenue Recognition [Abstract]      
Period to complete IND-enabling animal studies     12 months
Period to complete Phase 1 clinical trial     1 year
Period to complete Phase 2 clinical trial     1 year
Period to complete Phase 3 clinical trial     2 years
Period to prepare and submit regulatory filings     6 months
Period to obtain marketing authorization from applicable regulatory agency     1 year
Pre-specified product sales threshold included in commercialization milestones     $ 1,000.0
Maximum [Member]      
Revenue Recognition [Abstract]      
Period to complete IND-enabling animal studies     18 months
Period to complete Phase 1 clinical trial     2 years
Period to complete Phase 2 clinical trial     3 years
Period to complete Phase 3 clinical trial     4 years
Period to prepare and submit regulatory filings     12 months
Period to obtain marketing authorization from applicable regulatory agency     2 years
Novartis [Member]      
Revenue Recognition [Abstract]      
Number of agreements | Agreement   2  
Upfront payment received   $ 75.0  
Number of drugs with exclusive option that could be exercised | Drug   1  
Number of units of accounting | AccountingUnit     4
Allocable arrangement consideration     $ 108.4
Premium received on shares issued by Ionis   $ 28.4  
Premium received if IPO is not completed within 15 months from inception of agreement   $ 5.0 $ 5.0
Number of months from inception of agreement for IPO to be completed     15 months
Novartis [Member] | Subsequent Event [Member]      
Revenue Recognition [Abstract]      
Proceeds from sale of common stock $ 50.0    
Novartis [Member] | AKCEA-APO(a)-L [Member]      
Revenue Recognition [Abstract]      
Consideration allocated to development activities     $ 64.0
Consideration allocated to delivery of API     1.5
Novartis [Member] | AKCEA-APOCIII-L [Member]      
Revenue Recognition [Abstract]      
Consideration allocated to development activities     40.1
Consideration allocated to delivery of API     $ 2.8
Novartis SPA [Member] | Private Placement [Member] | Subsequent Event [Member]      
Revenue Recognition [Abstract]      
Proceeds from sale of common stock $ 50.0    
Ionis [Member] | Novartis SPA [Member]      
Revenue Recognition [Abstract]      
Shares issued (in shares) | shares   1.6  
Proceeds from sale of common stock   $ 100.0