Development, Commercialization and License Agreement and Services Agreement with Ionis (Tables)

6 Months Ended

Jun. 30, 2017

Development, Commercialization and License Agreement and Services Agreement with Ionis [Abstract]

Operating Expenses Generated by Transactions with Ionis

The following table summarizes the amounts included in our operating expenses that were generated by transactions with Ionis for the following periods (in thousands):

	Three Months Ended June 30,					Six Months Ended June 30,
	2017			2016		2017			2016
Services performed by Ionis	$	2,998		$	2,059	$	5,955		$	4,112
Active pharmaceutical ingredient manufactured by Ionis		2,930			—		6,013			—
Sublicensing expenses		—			—		48,394			—
Out-of-pocket expenses paid by Ionis		5,316			8,123		17,189			17,974
Total expenses generated by transactions with Ionis		11,244			10,182		77,551			22,086
Payable balance to Ionis at the beginning of the period		15,000			21,102	$	24,355			9,198
Less: total amounts paid to Ionis during the period		(15,000	)		—		(57,268	)		—
Less: non-cash sublicensing expenses		—			—		(33,394	)		—
Total amount payable to Ionis at period end	$	11,244		$	31,284	$	11,244		$	31,284