<SEC-DOCUMENT>0001104659-18-041089-index.html : 20180620
<SEC-HEADER>0001104659-18-041089.hdr.sgml : 20180620
<ACCEPTANCE-DATETIME>20180619184238
ACCESSION NUMBER:		0001104659-18-041089
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20180620
DATE AS OF CHANGE:		20180619
EFFECTIVENESS DATE:		20180620

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AKCEA THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001662524
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				472608175
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-225730
		FILM NUMBER:		18908276

	BUSINESS ADDRESS:	
		STREET 1:		55 CAMBRIDGE PARKWAY
		STREET 2:		SUITE 100
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		760-603-2732

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE CT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>a18-15557_1s8.htm
<DESCRIPTION>S-8
<TEXT>
Document 1 - file: a18-15557_1s8.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>a18-15557_1ex5d1.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 2 - file: a18-15557_1ex5d1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>a18-15557_1ex23d1.htm
<DESCRIPTION>EX-23.1
<TEXT>
Document 3 - file: a18-15557_1ex23d1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g155571kgi001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g155571kgi001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g155571kgi002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g155571kgi002.jpg

</DOCUMENT>
</SEC-DOCUMENT>