X0306 4 2022-05-05 0 0001159036 HALOZYME THERAPEUTICS, INC. HALO 0001662521 Connaughton Bernadette C/O HALOZYME THERAPEUTICS, INC. 11388 SORRENTO VALLEY ROAD SAN DIEGO CA 92121 1 0 0 0 Restricted Stock Units 2022-05-05 4 A 0 6206 0 A 38219 D Represents annual restricted stock unit grant under the Issuer's director compensation program. This grant will vest in full on the earlier of (i) May 5, 2023 and (ii) the date of the Issuer's next annual meeting of stockholders. /s/ James R. Oehler as attorney-in-fact for Bernadette Connaughton 2022-05-06