Short-Term Investments - Summary of Investments Included in Cash Equivalents and Short Term Investments (Details) - USD ($) $ in Thousands	Dec. 31, 2019	Sep. 30, 2019
Schedule Of Cash Cash Equivalents And Available For Sale Securities [Line Items]
Cash equivalents and short-term investments, Amortized Cost	$ 261,955	$ 177,753
Cash equivalents and short-term investments, Unrealized Gains	183
Cash equivalents and short-term investments, Fair Value	262,138	177,753
Money Market Mutual Funds
Schedule Of Cash Cash Equivalents And Available For Sale Securities [Line Items]
Cash equivalents and short-term investments, Amortized Cost	39,524	177,753
Cash equivalents and short-term investments, Fair Value	39,524	$ 177,753
Repurchase Agreements
Schedule Of Cash Cash Equivalents And Available For Sale Securities [Line Items]
Cash equivalents and short-term investments, Amortized Cost	14,000
Cash equivalents and short-term investments, Fair Value	14,000
Commercial Paper
Schedule Of Cash Cash Equivalents And Available For Sale Securities [Line Items]
Cash equivalents and short-term investments, Amortized Cost	41,259
Cash equivalents and short-term investments, Fair Value	41,259
Asset-backed Securities
Schedule Of Cash Cash Equivalents And Available For Sale Securities [Line Items]
Cash equivalents and short-term investments, Amortized Cost	14,866
Cash equivalents and short-term investments, Unrealized Gains	10
Cash equivalents and short-term investments, Fair Value	14,876
Corporate Debt Securities
Schedule Of Cash Cash Equivalents And Available For Sale Securities [Line Items]
Cash equivalents and short-term investments, Amortized Cost	92,380
Cash equivalents and short-term investments, Unrealized Gains	128
Cash equivalents and short-term investments, Fair Value	92,508
U.S Treasury Securities
Schedule Of Cash Cash Equivalents And Available For Sale Securities [Line Items]
Cash equivalents and short-term investments, Amortized Cost	59,926
Cash equivalents and short-term investments, Unrealized Gains	45
Cash equivalents and short-term investments, Fair Value	$ 59,971

Schedule of cash, cash equivalents and available-for-sale securities.

No definition available.

Name:	fixx_ScheduleOfCashCashEquivalentsAndAvailableForSaleSecuritiesLineItems
Namespace Prefix:	fixx_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

- Definition

Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=121645371&loc=d3e27161-111563

+ Details

Name:	us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Definition

Amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=121645371&loc=d3e27161-111563

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 326
-SubTopic 30
-Section 45
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=121558606&loc=SL82898722-210454

+ Details

Name:	us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant

- Definition

Amount of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 210
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-03(6))
-URI http://asc.fasb.org/extlink&oid=120398452&loc=d3e534808-122878

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 326
-SubTopic 30
-Section 45
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=121558606&loc=SL82898722-210454

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 45
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=121553693&loc=d3e26610-111562

Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 320
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (aa)
-URI http://asc.fasb.org/extlink&oid=121645371&loc=d3e27161-111563

+ Details

Name:	us-gaap_AvailableForSaleSecuritiesDebtSecurities
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant

- Details

Name:	us-gaap_CashAndCashEquivalentsAxis=us-gaap_MoneyMarketFundsMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_InvestmentTypeAxis=us-gaap_RepurchaseAgreementsMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_InvestmentTypeAxis=us-gaap_CommercialPaperMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_InvestmentTypeAxis=us-gaap_AssetBackedSecuritiesMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_InvestmentTypeAxis=us-gaap_CorporateDebtSecuritiesMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

- Details

Name:	us-gaap_InvestmentTypeAxis=us-gaap_USTreasurySecuritiesMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type: