Commitments and Contingencies - Additional Information (Detail)	1 Months Ended	4 Months Ended	12 Months Ended
	Dec. 31, 2021 USD ($) ft²	Dec. 31, 2019 USD ($) shares	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2021 USD ($) ft²	Jul. 31, 2024 USD ($)	Sep. 30, 2019 USD ($)
Commitment And Contingencies [Line Items]
Lease expiration date					Dec. 31, 2031
Operating lease liability, current			$ 612,000	$ 538,000
Research and development expenses			48,143,000	31,729,000
Executive insurance reserve			5,000,000
License Agreement With The University Of Colorado [Member]
Commitment And Contingencies [Line Items]
Development and sales milestone payment payable			$ 2,200,000
Percentage of sublicense fees			15.00%
Period of obligation to pay royalties			20 years
Research and development expenses			$ 0	$ 0
License Agreement With Bristol Mayers Equib Company [Member]
Commitment And Contingencies [Line Items]
Percentage of sublicense fees		60.00%
Period of obligation to pay royalties		12 years
Upfront payment made		$ 8,000,000
Commercial milestone payment payable							$ 215,000,000
Royalty as a percentage of sales		10.00%
Development Milestone Payment Payable						$ 4,000,000
License Agreement With Bristol Mayers Equib Company [Member] | Maximum [Member] | Tranche Three [Member]
Commitment And Contingencies [Line Items]
Development and sales milestone payment payable							49,000,000
License Agreement With Bristol Mayers Equib Company [Member] | Minimum [Member] | Tranche Three [Member]
Commitment And Contingencies [Line Items]
Development and sales milestone payment payable							$ 32,000,000
License Agreement With Bristol Mayers Equib Company [Member] | Series A Redeemable Preferred Stock [Member]
Commitment And Contingencies [Line Items]
Stock issued during period shares purchase of assets | shares		6,628,788
Waltham Massauchets [Member]
Commitment And Contingencies [Line Items]
Office space leased | ft²	15,000				15,000
Lessee, operating lease, lease not yet commenced, renewal term	5 years				5 years
Sublease aggregate base rent obligation	$ 1,000,000				$ 1,000,000
Percentage increase in initial annual base rent per square foot.	3.00%
Annual Rent Operating lease Aggregate After Increase	$ 11,100,000
Security deposit			$ 600,000
Operating lease weighted average remaining lease term			7 years
Operating lease weighted average discount rate			7.50%
Future minimum lease payment due under this sublease			$ 1,000,000
Operating lease liability, current			0
Waltham Massauchets [Member] | Restricted Cash And Cash Equivalents Non Current [Member]
Commitment And Contingencies [Line Items]
Lessee tenant improvement allowance			$ 400,000