Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Income Tax Disclosure [Line Items]
Tax provision	$ 0	$ 715,000
Net operating loss carryforwards	400,000
Uncertain tax positions	0
Income tax expense, interest or penalties	0	$ 0
Research and Development
Income Tax Disclosure [Line Items]
Tax credit carryforwards	65,500,000
Orphan Drug
Income Tax Disclosure [Line Items]
Tax credit carryforwards	$ 50,700,000
Tax credit carryforwards expiration year	2043
Federal
Income Tax Disclosure [Line Items]
Net operating loss carryforwards	$ 326,200,000
Net operating loss carryforwards indefinitely	$ 325,800,000
Net operating loss carryforwards expiration year	2035
Federal | Research and Development
Income Tax Disclosure [Line Items]
Tax credit carryforwards	$ 65,500,000
State
Income Tax Disclosure [Line Items]
Net operating loss carryforwards	317,300,000
State | Research and Development
Income Tax Disclosure [Line Items]
Tax credit carryforwards	$ 17,200,000