Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Line Items]
Income tax expense	$ 715,000	$ 0
Net operating loss carryforwards	400,000
Uncertain tax positions	0
Income tax expense, interest or penalties	0	$ 0
Research and Development
Income Tax Disclosure [Line Items]
Tax credit carryforwards	55,100,000
Orphan Drug
Income Tax Disclosure [Line Items]
Tax credit carryforwards	$ 45,200,000
Tax credit carryforwards expiration year	2041
Federal
Income Tax Disclosure [Line Items]
Net operating loss carryforwards	$ 283,500,000
Net operating loss carryforwards indefinitely	$ 283,100,000
Net operating loss carryforwards expiration year	2035
Federal | Research and Development
Income Tax Disclosure [Line Items]
Tax credit carryforwards	$ 55,100,000
State
Income Tax Disclosure [Line Items]
Net operating loss carryforwards	272,100,000
State | Research and Development
Income Tax Disclosure [Line Items]
Tax credit carryforwards	$ 14,800,000