License Agreements - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended
	Sep. 30, 2016	Dec. 31, 2022	Dec. 31, 2021
License Agreement [Line Items]
Collaboration agreement revenue recognized		$ 3,208	$ 33,971
Research and development		$ 98,351	$ 93,085
Common stock, shares issued		57,483,910	57,150,274
City of Hope
License Agreement [Line Items]
Annual license fee		$ 25,000
City of Hope | Maximum
License Agreement [Line Items]
Development and commercialization milestone payment		3,200
City of Hope | January 2023
License Agreement [Line Items]
Amount paid to related party upon dosing the first patient		50,000
California Institute Of Technology | Maximum | Co Exclusive License Agreement
License Agreement [Line Items]
Development and regulatory milestone payments	$ 7,200
California Institute Of Technology | Minimum | Co Exclusive License Agreement
License Agreement [Line Items]
Annual minimal royalty fee	$ 20,000
Novartis
License Agreement [Line Items]
Collaboration agreement revenue recognized			$ 26,900
Novartis | Collaborative Arrangement
License Agreement [Line Items]
Collaboration revenue			0
Collaboration agreement revenue recognized			30,800
Deferred revenue		0	0
Accounts receivable		$ 0	0
Novartis | Collaborative Arrangement | Deferred Revenue
License Agreement [Line Items]
Collaboration agreement revenue recognized			$ 30,200