Collaboration and License Agreement - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration agreement revenue recognized	$ 802	$ 1,677	$ 2,406	$ 33,169
Novartis
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration agreement revenue recognized			26,900
Novartis | Collaborative Arrangement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration Revenue			0
Collaboration agreement revenue recognized		$ 900		$ 30,800
Deferred revenue	800		800		$ 30,200
Accounts receivable	$ 0		$ 0