Stock Incentive Plans - Summary of Option Activity under Plans (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended	12 Months Ended
Mar. 31, 2022	Dec. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Number of Options, Outstanding at Beginning Balance	7,624,306
Number of Options, Granted	2,581,980
Number of Options, Exercised	(293)
Number of Options, Cancelled/Forfeited	(199,264)
Number of Options, Outstanding at Ending Balance	10,006,729	7,624,306
Number of Options, Vested and expected to vest at March 31, 2022	10,006,729
Number of Options, Exercisable at March 31, 2022	4,874,177
Weighted-Average Exercise Price per Share, Outstanding at Beginning Balance	$ 14.25
Weighted-Average Exercise Price per Share, Granted	2.80
Weighted-Average Exercise Price per Share, Exercised	2.71
Weighted-Average Exercise Price per Share, Cancelled/Forfeited	12.31
Weighted-Average Exercise Price per Share, Outstanding at Ending Balance	11.33	$ 14.25
Weighted-Average Exercise Price per Share, Vested and Expected to vest at March 31, 2022	11.33
Weighted-Average Exercise Price Per Share, Exercisable at March 31, 2022	$ 13.68
Weighted Average Remaining Contractual Term, Outstanding	7 years 9 months 18 days	7 years 6 months
Weighted Average Remaining Contractual Term, Vested and Expected to vest at March 31, 2022	7 years 9 months 18 days
Weighted Average Remaining Contractual Term, Exercisable at March 31, 2022	6 years 6 months
Aggregate Intrinsic Value, Outstanding Ending Balance	$ 2,415	$ 2,069
Aggregate Intrinsic Value, Vested and Expected to vest at March 31, 2022	2,415
Aggregate Intrinsic Value, Exercisable at March 31, 2022	$ 1,676

Share based compensation arrangement by share based payment award options exercised in period gross.

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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For presentations that combine terminations, the number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan or that expired.

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Weighted average price of options that were either forfeited or expired.

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Gross number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Amount by which current fair value of underlying stock exceeds exercise price of fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for fully vested and expected to vest options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.

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