X0202 SCHEDULE 13G/A 0000919574-26-003211 0002115022 XXXXXXXX LIVE 1 Common Stock, par value $0.0001 per share 06/30/2026 0001661998 Q32 Bio Inc. 746964105 830 WINTER STREET WALTHAM MA 02451 Rule 13d-1(b) Sirenia Capital Management LP b DE 0.00 0.00 0.00 0.00 0.00 N 0 IA PN Alex Silverstein b X1 0.00 0.00 0.00 0.00 0.00 N 0 HC IN Q32 Bio Inc. 830 Winter Street, Waltham, Massachusetts 02451 This statement is filed by: (i) Sirenia Capital Management LP ("Sirenia") with respect to the common stock, par value $0.0001 per share ("Common Stock"), of Q32 Bio Inc. that was held by investment funds it manages (the "Sirenia Funds"); and (ii) Alex Silverstein ("Mr. Silverstein"), the managing member of Sirenia Capital Management GP LLC, the general partner of Sirenia, with respect to the Common Stock that was held by the Sirenia Funds. The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." The address of the principal business office of Sirenia and Mr. Silverstein is 1674 Meridian Avenue, Suite 320, Miami Beach, FL 33139. Sirenia is a Delaware limited partnership. Mr. Silverstein is a United States citizen. N IA HC The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. 0% The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. N Y Y N See Item 2(a) and Item 3. Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Sirenia Capital Management LP /s/ Kolby Loft 08/14/2026 Alex Silverstein /s/ Alex Silverstein 08/14/2026