X0306 4 2023-03-02 0 0001661998 Homology Medicines, Inc. FIXX 0001916155 Alloway Paul C/O HOMOLOGY MEDICINES, INC. ONE PATRIOTS PARK BEDFORD MA 01730 0 1 0 0 See Remarks Common Stock 2023-03-02 4 S 0 10965 1.4467 D 16706 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 24, 2022. This transaction reports the sale of 10,965 shares which were acquired on February 28, 2023 pursuant to the Issuer's Employee Stock Purchase Plan. The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $1.37 to $1.52. The Reporting Person undertakes to provide upon request the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote 3. Chief Legal Officer and Secretary /s/ Paul Alloway 2023-03-06