X0306 4/A 2023-01-09 2023-01-11 0 0001661998 Homology Medicines, Inc. FIXX 0001916500 Blum Michael Lee C/O HOMOLOGY MEDICINES, INC. ONE PATRIOTS PARK BEDFORD MA 01730 0 1 0 0 Chief Commercial Officer Common Stock 9408 D This amended Form 4 is being filed to correct the aggregate common stock holdings of the Reporting Person. On each of January 4, 2023 and January 11, 2023, the Reporting Person filed a Form 4 that inadvertently re-reported Employee Stock Purchase Plan ("ESPP") shares that were previously reported. Accordingly, the common stock holdings in column 5 of Table I have been reduced by 630 ESPP shares. /s/ Paul Alloway, Attorney-in-Fact for Michael L. Blum 2023-01-20