X0306 4 2023-01-09 0 0001661998 Homology Medicines, Inc. FIXX 0001916155 Alloway Paul C/O HOMOLOGY MEDICINES, INC. ONE PATRIOTS PARK BEDFORD MA 01730 0 1 0 0 See Remarks Common Stock 2023-01-09 4 S 0 3090 1.3903 D 20103 D The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 instruction solely with the intent to cover withholding taxes in connection with the settlement of restricted stock units. The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $1.39 to $1.40. The Reporting Person undertakes to provide upon request the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote 2. Chief Legal Officer and Secretary /s/ W. Bradford Smith, Attorney-in-Fact for Paul Alloway 2023-01-11