X0206 3 2022-08-22 0 0001178670 ALNYLAM PHARMACEUTICALS, INC. ALNY 0001661908 Sigal Charles Elliott 675 WEST KENDALL STREET HENRI A. TERMEER SQUARE CAMBRIDGE MA 02142 1 0 0 0 Common Stock 2000 I by Trust Shares held by Sigal Family Investments, LLC, of which the reporting person is Managing Member. By: /s/ Stephen Hall, Attorney-in-Fact For: Charles Elliott Sigal 2022-08-24