X0206 3 2016-01-01 0 0001621227 Adaptimmune Therapeutics PLC ADAP 0001661908 Sigal Charles Elliott 32 BREARLY ROAD PRINCETON NJ 08540 1 0 0 0 Ordinary Shares with a nominal value of GBP0.001 per share 254100 I Shares held by Sigal Family Investments, LLC Ordinary Shares with a nominal value of GBP0.001 per share 52938 D Option to purchase Ordinary Shares 0.7400 2025-03-16 Ordinary Shares 519481 D Option to purchase Ordinary Shares 2.8379 2015-05-11 2025-05-11 Ordinary Shares 24596 D Dr. Sigal is a manager of Sigal Family Investments, LLC. Dr. Sigal may be deemed to have voting and investment power over the shares held by Sigal Family Investments, LLC. Dr. Sigal disclaims beneficial ownership of such shares except to the extent of any pecuniary interest therein. Represented by 8,823 American Depositary Shares ("ADSs") held by Dr. Sigal. Dr. Sigal holds these Ordinary Shares in the form of ADSs. Each ADS represents six Ordinary Shares of Adaptimmune Therapeutics plc. Exercisable as to 129,870 Ordinary Shares on March 16, 2016 and will be exercisable as to the remainder in monthly installments of 10,822 Ordinary Shares on the sixteenth of each month from April 16, 2016 through February 16, 2019, and in one installment of 10,841 Ordinary Shares on March 16, 2019. The exercise price was converted from GBP0.50 based on the noon buying rate of the Federal Reserve Bank of New York for the U.S. dollar on the date of grant. The actual exercise price will be the pounds sterling amount regardless of the exchange rate on the date of grant or of exercise. The exercise price was converted from GBP1.82 based on the noon buying rate of the Federal Reserve Bank of New York for the U.S. dollar on the date of grant. The actual exercise price will be the pounds sterling amount regardless of the exchange rate on the date of grant or of exercise. /s/ Charles Elliott Sigal Name: Charles Elliott Sigal 2016-01-04