X0508 4 2023-08-02 0 0001346830 Cara Therapeutics, Inc. CARA 0001661481 Boudreau Helen M C/O CARA THERAPEUTICS, INC. 4 STAMFORD PLAZA, 107 ELM STREET, 9TH FL STAMFORD CT 06902 1 0 0 0 0 Stock Option (Right to Buy) 3.09 2023-08-02 4 A 0 155747 0.00 A 2033-08-02 Common Stock 155747 155747 D This option shall vest and become exercisable in twelve (12) equal quarterly installments beginning on August 2, 2023 such that the option will be fully vested and exercisable on August 2, 2026, subject to the Reporting Person's continued service to the Issuer on each such date. /s/Darren DeStefano, Attorney-in-Fact 2023-08-04