X0508 4 2025-12-16 0001661181 Organogenesis Holdings Inc. ORGO 0001244191 NUSSDORF GLENN H 35 SAWGRASS DRIVE BELLPORT NY 11713 1 0 0 0 0 Class A Common Stock 2025-12-16 4 S 0 200000 5.1353 D 2565591 D Class A Common Stock 918680 I By GN 2016 Family Trust u/a/d August 12, 2016 Class A Common Stock 7928570 I By GN 2016 Organo 10-Year GRAT u/a/d September 30, 2016 Class A Common Stock 335719 I By Glenn Nussdorf 10 Year Follow On Trust Dated 11-1-1998 The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $5.10 to $5.24, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4. /s/ William R. Kolb, Attorney-in-Fact 2025-12-18