X0306 4 2022-06-06 0001661181 Organogenesis Holdings Inc. ORGO 0001074084 ERANI ALBERT C/O RUGBY REALTY CO., INC. 300 LIGHTING WAY, STE 210 SECAUCUS NJ 07094 0 0 1 0 0001900525 RED Holdings, LLC C/O RUGBY REALTY CO., INC. 300 LIGHTING WAY, STE 210 SECAUCUS NJ 07094 0 0 1 0 0001757452 GN 2016 Organo 10-Year GRAT u/a/d September 30, 2016 35 SAWGRASS DRIVE BELLPORT NY 11713 0 0 1 0 0001760685 Erani Dennis 6000 ISLAND BOULEVARD APT. 2502 AVENTURA FL 33160 0 0 1 0 Class A Common Stock 2022-06-06 4 S 0 100000 5.41 D 59348027 D Class A Common Stock 2022-06-07 4 S 0 50000 5.49 D 59298027 D Class A Common Stock 2022-06-08 4 S 0 20000 5.39 D 59278027 D The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $5.30 to $5.55, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $5.33 to $5.54, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $5.34 to $5.49, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4. Reflects the total number of securities held by the Group. Only Albert Erani has a pecuniary interest in the shares being sold pursuant to this Form 4. None of the other members of the Group has a pecuniary interest in the shares being sold pursuant to this Form 4. Alan A. Ades, Albert Erani, Glenn H. Nussdorf, Dennis Erani, Starr Wisdom and certain of their respective affiliates, including Organo PFG LLC, Organo Investors LLC, Dennis Erani 2012 Issue Trust, Alan Ades as Trustee of the Alan Ades 2014 GRAT, Albert Erani Family Trust dated 12/29/2012, GN 2016 Family Trust u/a/d August 12, 2016, GN 2016 Organo 10-Year GRAT u/a/d September 30, 2016 and RED Holdings, LLC, referred to collectively as the "Group", are parties to a Controlling Stockholders' Agreement dated December 10, 2018 with Organogenesis Holdings Inc. (the "Stockholders' Agreement"). The Stockholders' Agreement, among other things, provides for nomination rights of the Group with respect to four directors of the Issuer. As a result of the Stockholders' Agreement, the reporting persons may be deemed to be members of a group holding over 10% of the outstanding shares of common stock of the issuer for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended. This is Form 4 No. 2 of 2 filed for the Group. /s/ William R. Kolb, Attorney-in-Fact 2022-06-08