X0306 4 2022-05-18 0001661181 Organogenesis Holdings Inc. ORGO 0001757373 Gillheeney Gary S. C/O ORGANOGENESIS HOLDINGS INC. 85 DAN ROAD CANTON MA 02021 1 1 0 0 President and CEO Class A Common Stock 2022-05-18 4 M 0 86531 0.99 A 484773 D Class A Common Stock 2022-05-18 4 S 0 86531 5.46 D 398242 D Class A Common Stock 2022-05-19 4 M 0 118504 0.99 A 516746 D Class A Common Stock 2022-05-19 4 S 0 118504 5.94 D 398242 D Class A Common Stock 2022-05-20 4 M 0 58654 0.99 A 456896 D Class A Common Stock 2022-05-20 4 S 0 58654 5.89 D 398242 D Stock Option (Right to Buy) 0.99 2022-05-18 4 M 0 86531 0 D 2024-12-08 Class A Common Stock 86531 1251073 D Stock Option (Right to Buy) 0.99 2022-05-19 4 M 0 118504 0 D 2024-12-08 Class A Common Stock 118504 1132569 D Stock Option (Right to Buy) 0.99 2022-05-20 4 M 0 58654 0 D 2024-12-08 Class A Common Stock 58654 1073915 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person in March 2022. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $5.39 to $5.62, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $5.45 to $6.11, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $5.75 to $6.04, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4. 100% of the shares subject to the option are fully vested and exercisable. /s/ William R. Kolb, Attorney-in-Fact 2022-05-20