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Related Party Transactions - (Details) - USD ($)
1 Months Ended 9 Months Ended 12 Months Ended
Nov. 05, 2018
Nov. 02, 2018
Nov. 30, 2018
Dec. 31, 2015
Sep. 30, 2018
Dec. 31, 2018
Dec. 31, 2017
Related Party Transactions              
Equity investment   $ 15,000,000     $ 31,000,000 $ 122,223,000 $ 25,000,000
Series B-3 preferred stock              
Related Party Transactions              
Equity investment $ 93,400,000   $ 15,000,000        
Lilly Agreement              
Related Party Transactions              
Upfront non-refundable payment received   25,000,000          
Equity investment   $ 15,000,000          
Lilly Agreement | Lilly              
Related Party Transactions              
Upfront non-refundable payment received     25,000,000        
Lilly Agreement | Lilly | Series B-3 preferred stock              
Related Party Transactions              
Equity investment     $ 15,000,000        
Consulting Agreement | Scientific Founder              
Related Party Transactions              
Monthly consulting fees       $ 5,000      
Amount due to related party           120,000  
Yale License Agreement | Yale University              
Related Party Transactions              
Milestone payments per product       3,000,000      
Sponsored Research Agreement | Yale University              
Related Party Transactions              
Amount provided to fund research program       $ 12,400,000      
Aggregate payments made           7,400,000  
Payments made to related party           $ 2,500,000 $ 2,100,000