SCHEDULE 13G/A 0000078003 XXXXXXXX LIVE 1 Common Stock par value $0.001 per share 12/31/2025 0001661059 NEXTCURE, INC. 65343E108 9000 Virginia Manor Road Suite 200 Beltsville MD 20705 Rule 13d-1(c) Pfizer Inc. (IRS Identification No.: 13-5315170) DE 26537.00 131109.00 26537.00 131109.00 157646.00 N 3.0 CO Percent of class outstanding is based on a total of 5,203,290 shares of common stock outstanding, as reported in the Issuer's final prospectus filed with the Securities and Exchange Commission on Decmeber 11, 2025 (including 1,815,049 shares of common stock issuable upon the exercise of the Pre- Funded Warrants held by the selling stockholders). Pfizer Ventures (US) LLC (IRS Indentification No. 82-5524518 ) DE 0.00 131109.00 0.00 131109.00 131109.00 N 2.5 OO Percent of class outstanding is based on a total of 5,203,290 shares of common stock outstanding, as reported in the Issuer's final prospectus filed with the Securities and Exchange Commission on Decmeber 11, 2025 (including 1,815,049 shares of common stock issuable upon the exercise of the Pre- Funded Warrants held by the selling stockholders). NEXTCURE, INC. 9000 Virginia Manor Road, Suite 200, Beltsville, Maryland, 20705 Pfizer Inc. ("Pfizer") and Pfizer Venture (US) LLC ("PVUS" and together with Pfizer, the "Reporting Person"). PVUS is a controlled affiliate of Pfizer. 66 Hudson Boulevard East, New York, NY10001-2192 Delaware Y See the respective responses of the Reporting Persons to Item 9 on the attached cover pages. See the respective responses of the Reporting Persons to Item 11 on the attached cover pages. See the respective responses of the Reporting Persons to Item 5 on the attached cover pages. See the respective responses of the Reporting Persons to Item 6 on the attached cover pages. See the respective responses of the Reporting Persons to Item 7 on the attached cover pages. See the respective responses of the Reporting Persons to Item 8 on the attached cover pages. N Y N Not applicable N Not applicable N Not applicable N Not applicable N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Pfizer Inc. (IRS Identification No.: 13-5315170) /s/ Madelyn D. Purcell 02/13/2026 Pfizer Ventures (US) LLC (IRS Indentification No. 82-5524518 ) /s/ Esther Louis 02/13/2026