X0202 SCHEDULE 13G/A 0001193125-21-276241 0001224962 XXXXXXXX LIVE 8 Common Stock, $0.00001 par value 06/30/2026 0001661053 enVVeno Medical Corporation 29415J205 70 Doppler Irvine CA 92618 Rule 13d-1(c) Perceptive Advisors LLC b DE 0 24605 0 24605 24605 N 3.5 IA Joseph Edelman b X1 0 24605 0 24605 24605 N 3.5 IN Perceptive Life Sciences Master Fund, Ltd. b E9 0 24605 0 24605 24605 N 3.5 enVVeno Medical Corporation 70 Doppler, Irvine, California 92618 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.00001 per share (the "Common Stock") of enVVeno Medical Corporation (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover pages to this Schedule 13G. The ownership percentages are based on 682,722 shares of Common Stock outstanding as of July 28, 2026, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on July 30, 2026, and assume the exercise of warrants (the "Warrants") held by the Reporting Persons for 24,605 shares of Common Stock. Neither Perceptive Advisors nor Mr. Edelman directly holds any shares of Common Stock or any Warrants. The Master Fund directly holds 24,605 Warrants, each immediately exercisable for shares of Common Stock, subject to the Beneficial Ownership Limitation (as defined below). The terms of the Warrants provide that the Warrants may not be exercised if, after such exercise, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 9.99% of the shares of Common Stock then issued and outstanding (the "Beneficial Ownership Limitation"). As of the date hereof, the Beneficial Ownership Limitation permits the Reporting Persons to exercise all of their Warrants. Perceptive Advisors serves as the investment manager of the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors. Perceptive Advisors: 3.5% Mr. Edelman: 3.5% Master Fund: 3.5% Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 24,605 Mr. Edelman: 24,605 Master Fund: 24,605 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 24,605 Mr. Edelman: 24,605 Master Fund: 24,605 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 08/14/2026 Joseph Edelman /s/ Joseph Edelman 08/14/2026 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 08/14/2026