X0306 4 2016-02-05 0 0001660719 Aralez Pharmaceuticals Inc. ARLZ 0001441461 Glickman Mark A C/O ARALEZ PHARMACEUTICALS INC. 2800 PARK PLACE 666 BURRARD STREET VANCOUVER A1 V6C2Z7 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief Commercial Officer Common Shares 2016-02-05 5 J 0 E 29137 0 A 29137 D Reflects the beneficial ownership of the reporting person following consummation of the business transaction among POZEN Inc. ("Pozen"), Tribute Pharmaceuticals Canada Inc. ("Tribute") and the Registrant on February 5, 2016, pursuant to the Agreement and Plan of Merger and Arrangement as entered into on June 8, 2015 and as amended on August 19, 2015 and December 7, 2015 among Pozen, Tribute, the Registrant, Aralez Pharmaceuticals Holdings Limited, ARLZ US Acquisition II Corp., and ARLZ CA Acquisition Corp. (the "Merger"). Represents 29,137 shares issuable pursuant to Restricted Stock Units previously granted by Pozen, predecessor to the Registrant. /s/ Eric L. Trachtenberg, attorney-in -fact for Mark A. Glickman 2016-02-09