License and Collaboration Agreements - Additional Information (Detail) - USD ($) $ in Thousands		1 Months Ended					3 Months Ended		6 Months Ended		12 Months Ended
	Mar. 17, 2021	May 31, 2022	Apr. 30, 2021	Feb. 28, 2021	Dec. 31, 2020	Aug. 31, 2020	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021	Dec. 31, 2020
License And Collaboration Agreements [Line Items]
Research and development expense							$ 4,162	$ 3,447	$ 6,885	$ 8,809
Ltyix [Member]
License And Collaboration Agreements [Line Items]
Payments upon achievements of milestone						$ 111,000
One time up front license fee		$ 1,000		$ 2,300								$ 300
Research and development expense									1,000		$ 2,300
Percentage of royalty income shared						50.00%
Option Agreement [Member] | Torii [Member]
License And Collaboration Agreements [Line Items]
Consideration receivable to secure exclusive option						$ 500
Deferred revenue					$ 500							$ 500
Torii Agreement [Member] | Torii [Member]
License And Collaboration Agreements [Line Items]
Received payment			$ 11,500		$ 500
Payments upon achievements of milestone	$ 58,000
Billed and Unbilled License Revenue							$ 200		$ 600
Torii Agreement [Member] | Torii [Member] | Minimum [Member]
License And Collaboration Agreements [Line Items]
Mid Percentage of transfer price payments for supply of product net sales	30.00%
Torii Agreement [Member] | Torii [Member] | Maximum [Member]
License And Collaboration Agreements [Line Items]
Mid Percentage of transfer price payments for supply of product net sales	40.00%