<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>5/A</documentType>

    <periodOfReport>2018-12-31-07:00</periodOfReport>

    <dateOfOriginalSubmission>2019-01-14-07:00</dateOfOriginalSubmission>

    <notSubjectToSection16>false</notSubjectToSection16>

    <form3HoldingsReported>0</form3HoldingsReported>

    <form4TransactionsReported>0</form4TransactionsReported>

    <issuer>
        <issuerCik>0001474167</issuerCik>
        <issuerName>Cosmos Holdings Inc.</issuerName>
        <issuerTradingSymbol>COSM</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001660125</rptOwnerCik>
            <rptOwnerName>Siokas Grigorios</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>5 AG. GEORGIOU STR., PILEA</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>THESSALONIKI</rptOwnerCity>
            <rptOwnerState>J3</rptOwnerState>
            <rptOwnerZipCode>TK57001</rptOwnerZipCode>
            <rptOwnerStateDescription>GREECE</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>Chief Executive Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.001</value>
            </securityTitle>
            <transactionDate>
                <value>2017-10-02-06:00</value>
            </transactionDate>
            <deemedExecutionDate>
                <value>2017-10-02-06:00</value>
            </deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>5</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>false</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>100000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.22</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">On October 2, 2017, Ourania Matsouki purchased certain shares pursuant to a Stock Purchase Agreement (SPA) with a third party. The SPA was reported by Grigorios Siokas, Ms. Matsouki's husband, on Form 5 on January 14, 2019. However, the SPA was never completed. As such on May 29, 2019, Ms. Matsouki and the third party entered into a Rescission Agreement wherein the SPA was rescinded retroactively to the date of the SPA and the attempted purchase was deemed null and void.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Grigorios Siokas</signatureName>
        <signatureDate>2019-06-04-06:00</signatureDate>
    </ownerSignature>
</ownershipDocument>
