Note 6 - Stock based Compensation - Stock Option Activity (Details) - USD ($)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Outstanding, number of shares (in shares)	249,492
Outstanding, weighted average grant date fair value (in dollars per share)	$ 43.35
Outstanding, weighted average exercise price (in dollars per share)	$ 56.7
Outstanding, weighted average remaining contractual term (Year)	8 years 10 months 24 days	7 years 10 months 24 days
Outstanding, aggregate intrinsic value	$ 0	$ 378,606
Granted, number of shares (in shares)	542,667
Granted, weighted average grant date fair value (in dollars per share)	$ 2.01
Granted, weighted average exercise price (in dollars per share)	$ 2.52
Forfeited, number of shares (in shares)	(6,664)
Forfeited, weighted average grant date fair value (in dollars per share)	$ 13.9
Forfeited, weighted average exercise price (in dollars per share)	$ 16.5
Expired, number of shares (in shares)	(967)
Expired, weighted average grant date fair value (in dollars per share)	$ 15.44
Expired, weighted average exercise price (in dollars per share)	$ 18.3
Outstanding, number of shares (in shares)	784,528	249,492
Outstanding, weighted average grant date fair value (in dollars per share)	$ 15.03	$ 43.35
Outstanding, weighted average exercise price (in dollars per share)	$ 19.6	$ 56.7
Exercisable, number of shares (in shares)	156,413
Exercisable, weighted average grant date fair value (in dollars per share)	$ 60.35
Exercisable, weighted average exercise price (in dollars per share)	$ 80.04
Exercisable, weighted average remaining contractual term (Year)	6 years 2 months 12 days
Exercisable, aggregate intrinsic value	$ 0