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Note 6 - Equity (Details Textual) $ / shares in Units, $ in Thousands		1 Months Ended					3 Months Ended	12 Months Ended
	Jun. 15, 2020 shares	Jun. 30, 2021 USD ($) $ / shares shares	Feb. 28, 2021 USD ($) $ / shares shares	Jan. 31, 2021 USD ($) shares	Nov. 30, 2020 USD ($) shares	Feb. 28, 2020 USD ($) $ / shares shares	Mar. 22, 2022 shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($) $ / shares shares	Jul. 31, 2020 USD ($)	Jun. 30, 2020 shares	Jul. 31, 2019 USD ($)	Oct. 04, 2018 USD ($)
Preferred Stock, Shares Issued, Total (in shares)								0	0
Proceeds from Issuance of Common Stock \| $								$ 74,684	$ 22,561
Share Based Compensation Arrangement by Share Based Payment Award, Options, Grants in Period, Aggregate Fair Value \| $								1,700	1,300
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total \| $								$ 1,500	$ 1,500
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares)								534,865
Preferred Stock, Shares Outstanding, Ending Balance (in shares)								0	0
Subsequent Event [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares)							21,667
The 2015 Stock Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized (in shares)	1,000,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares)											1,750,001
Common Stock, Capital Shares Reserved for Future Issuance (in shares)								41,628
Share-based Payment Arrangement, Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year)								10 years
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total \| $								$ 2,800
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)								2 years 8 months 12 days
Share-based Payment Arrangement, Option [Member] \| Employees [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)								4 years
Share-based Payment Arrangement, Option [Member] \| Director [Member] \| Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)								1 year
Share-based Payment Arrangement, Option [Member] \| Director [Member] \| Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)								3 years
Restricted Stock Units (RSUs) [Member]
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total \| $								$ 800
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)								2 years 10 months 24 days
Share Based Compensation Arrangement by Share Based Payment Award, Number of Installment Periods		4						4
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period (in shares)		150,000						150,000
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share) \| $ / shares		$ 3.73						$ 3.73
Warrants Issued in Connection with the February 2020 Stock Offering [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)						937,501
Underwritten Public Offering [Member]
Stock Issued During Period, Shares, New Issues (in shares)			14,273,684
Shares Issued, Price Per Share (in dollars per share) \| $ / shares			$ 4.75
Proceeds from Issuance of Common Stock \| $			$ 78,000
Over-Allotment Option [Member]
Stock Issued During Period, Shares, New Issues (in shares)			2,141,052
February 2020 Stock Offering [Member]
Stock Issued During Period, Shares, New Issues (in shares)						1,250,000
Shares and Warrants Issued in Period, Purchase Price Per Share and Related Warrant (in dollars per share) \| $ / shares						$ 4.80
Proceeds from Issuance or Sale of Equity, Total \| $						$ 6,000
Payments of Stock Issuance Costs \| $						$ 700
Lincoln Park Transaction [Member]
Purchase Agreement, Common Stock, Maximum Aggregate Commitment \| $					$ 22,000								$ 20,000
Stock Issued During Period, Shares, Commitment Consideration (in shares)		107,788			126,699
Purchase Agreement, Maximum Aggregate Commitment, Number of Additional Shares Issued (in shares)		53,893
Stock Issued During Period, Value, Additional Commitment Shares \| $		$ 400			$ 500
Stock Issued During Period, Shares, Additional Commitment Shares (in shares)					50,680
The 2020 Purchase Agreement [Member]
Stock Issued During Period, Shares, New Issues (in shares)									771,220
Proceeds from Issuance of Common Stock \| $									$ 2,200
Stock Issued During Period, Shares, Additional Commitment Shares (in shares)									133,017
The 2021 ATM Agreement [Member]
Stock Issued During Period, Shares, New Issues (in shares)								0
At Market Issuance Sales Agreement, Maximum Aggregate Offering Price \| $		$ 50,000
The 2020 ATM Agreement [Member]
Stock Issued During Period, Shares, New Issues (in shares)				468,684					471,405
Proceeds from Issuance of Common Stock \| $				$ 2,900					$ 2,800
Payments of Stock Issuance Costs \| $									$ 100
At Market Issuance Sales Agreement, Maximum Aggregate Offering Price \| $										$ 15,000
Shares Issued, Average Price Per Share (in dollars per share) \| $ / shares									$ 6.11
Common Stock, Shares Subscribed but Unissued (in shares)									26,966
Common Stock Subscribed, Average Price Per Share (in dollars per share) \| $ / shares									$ 4.96
Common Stock, Value, Subscriptions \| $									$ 100
The 2019 ATM Agreement [Member]
Stock Issued During Period, Shares, New Issues (in shares)									1,412,017
Proceeds from Issuance of Common Stock \| $									$ 11,900
At Market Issuance Sales Agreement, Maximum Aggregate Offering Price \| $												$ 15,000
Shares Issued, Average Price Per Share (in dollars per share) \| $ / shares									$ 8.68
At Market Issuance Sales Agreement, Commission Fee, Percentage of Gross Proceeds												3.00%