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Note 5 - Warrants (Tables)
12 Months Ended
Dec. 31, 2021
Notes Tables  
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
  Number of Shares Under Outstanding Warrants at December 31, 2021  Number of Shares Under Outstanding Warrants at December 31, 2020  Weighted Average Exercise Price at December 31, 2021  

Remaining Contractual Life at December 31, 2021 (Years)

 

Liability Classified Warrants (1)

                

Issued February 2017

  67,349   67,349  $8.42   0.1 

Issued February 2018

  378,951   378,951   16.80   1.6 

Issued June 2018 (2)

  123,836   123,836   12.20   1.9 

Issued March 2019

  263,507   263,507   6.60   2.2 

Issued April 2019

  875,001   875,001   10.50   2.3 

Issued February 2020

  1,015,001   1,025,001   6.30   3.6 
   2,723,645   2,733,645  $9.46     

Equity Classified Warrants

                

Issued May 2016 - Bonwick

     17,970  $45.00    

Issued July 2017 - Consulting (3)

  25,001   25,001   15.64   0.6 

Issued April 2018 - Consulting

     16,667   18.00    

Issued August 2019 - Consulting

  25,000   25,000   9.84   0.6 

Issued April 2020 - Consulting

  16,667   16,667   6.84   3.3 

Issued December 2020 - Consulting

  8,334   8,334   4.72   4.0 

Issued April 2021 - Consulting

  71,500      3.63   4.3 

Issued August 2021 - Consulting

  250,000      3.08   9.6 
   396,502   109,639  $4.59     

Balance outstanding

  3,120,147   2,843,284  $8.51     
Schedule of Warrants or Rights, Assumptions Used [Table Text Block]
  

Year Ended December 31,

 
  

2021

  

2020

 

Risk-free interest rate

  0.1% to 1.1%   0.1% to 0.3% 

Volatility

  71.8% to 114.5%   113.7% to 127.4% 

Expected life (years)

  0.1 to 3.6   1.1 to 4.6 

Dividend yield

  

—%

   

—%

 
Schedule of Warrant Activity [Table Text Block]
  Number of Shares Under Warrant  Range of Warrant Exercise Price per Share  Weighted Average Exercise Price  

Weighted Average Remaining Contractual Life (Years)

 

Outstanding at December 31, 2020

  2,733,645  

6.60 to 16.80

  $9.45   3.6 

Granted

    

6.30 to 6.30

  $    

Exercised

  (10,000) 

6.60 to 6.60

  $6.60    

Expired

       $    

Outstanding at December 31, 2021

  2,723,645  6.30 to 16.80  $9.46   2.6 
                 

Vested and Exercisable at December 31, 2021

  2,723,645  6.30 to 16.80  $9.46   2.6