Collaboration Agreements - Additional Information (Details)					1 Months Ended	3 Months Ended	9 Months Ended
	Dec. 03, 2021 USD ($)	Oct. 01, 2021	Jun. 30, 2021 USD ($)	Jan. 02, 2019 Target	Apr. 30, 2021 Target	Jun. 30, 2022 USD ($)	Sep. 30, 2022 USD ($) Target	Sep. 30, 2021 USD ($)	Mar. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Collaboration Agreements [Line Items]
Deferred revenue							$ 1,363,000			$ 12,963,000
Deferred revenue							$ 17,605,000
Collaboration and License Agreement | Jazz Pharmaceuticals Ireland Limited
Collaboration Agreements [Line Items]
Number of targets | Target				4
Number of oncogene targets discontinue work | Target					1		2
Number of oncogene targets | Target				5			5
Remaining deferred revenue recognized								$ 10,900,000
Total collaboration revenue			$ 2,800,000			$ 13,300,000
Deferred revenue							$ 26,000,000.0		$ 12,600,000
Changes in estimate of variable consideration							0
Deferred revenue							17,600,000			$ 43,600,000
Sarepta Research Agreement
Collaboration Agreements [Line Items]
Remaining deferred revenue recognized							$ 600,000
Total collaboration revenue	$ 13,900,000
Effective contract termination date		Dec. 03, 2021