Collaboration Agreements - Additional Information (Details)					1 Months Ended	3 Months Ended		6 Months Ended
	Dec. 03, 2021 USD ($)	Oct. 01, 2021	Jun. 30, 2021 USD ($)	Jan. 02, 2019 Target	Apr. 30, 2021 Target	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($) Target	Jun. 30, 2021 USD ($)	Mar. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Collaboration Agreements [Line Items]
Total collaboration revenue						$ 13,145,000	$ 890,000	$ 25,849,000	$ 14,081,000
Deferred revenue						292,000		292,000			$ 12,963,000
Deferred revenue						17,633,000		$ 17,633,000
Collaboration and License Agreement | Jazz Pharmaceuticals Ireland Limited
Collaboration Agreements [Line Items]
Number of targets | Target				4
Number of oncogene targets discontinue work | Target					1			2
Number of oncogene targets | Target				5				5
Remaining deferred revenue recognized									$ 10,900,000
Total collaboration revenue			$ 2,800,000			13,300,000
Deferred revenue						26,000,000.0		$ 26,000,000.0		$ 12,600,000
Changes in estimate of variable consideration								0
Deferred revenue						$ 17,600,000		17,600,000			$ 43,600,000
Sarepta Research Agreement
Collaboration Agreements [Line Items]
Remaining deferred revenue recognized								$ 600,000
Total collaboration revenue	$ 13,900,000
Effective contract termination date		Dec. 03, 2021