Collaboration Agreements - Summary of Research and Development Costs Incurred and Revenue Recognized (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Collaboration Agreements [Line Items]
Revenue recognized	$ 13,312	$ 890	$ 26,016	$ 14,081
Sarepta Research Agreement
Collaboration Agreements [Line Items]
Revenue recognized	(167)	1,401	(167)	2,974
Costs incurred		1,401		2,974
Collaboration and License Agreement | Jazz Pharmaceuticals Ireland Limited
Collaboration Agreements [Line Items]
Revenue recognized	13,312	(511)	26,016	11,107
Costs incurred	$ 393	$ 677	$ 952	$ 1,341