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Income Taxes - Summary of Reconciliation of US Statutory Income Tax Rate to the Company's Effective Tax Rate (Detail)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Income Tax Disclosure [Abstract]    
Federal statutory income tax rate% 21.00% 21.00%
State taxes, net of federal benefit 8.50% 7.40%
Federal and state research and development credits 5.90% 2.70%
Executive Compensation (0.70%) (0.30%)
Non-deductible items (0.10%) (0.10%)
Stock Compensation (1.50%) (0.80%)
Change in valuation allowance (33.20%) (30.00%)
Other 0.10% 0.10%