Leases - Additional Information (Details)							12 Months Ended
	Nov. 15, 2021 USD ($) Renewal	Jul. 01, 2021	Apr. 27, 2020 USD ($) ft²	Aug. 26, 2019	Mar. 22, 2019 USD ($) ft²	Mar. 05, 2019 USD ($) ft²	Dec. 31, 2021 USD ($) ft² Office	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Lessee Lease Description [Line Items]
Lease expiration year							2029
Number of location | Office							2
Operating right-of-use assets obtained in exchange for operating lease liabilities							$ 1,034,000	$ 23,186,000
Sublease income							$ 1,850,000	861,000
500 Technology Square
Lessee Lease Description [Line Items]
Area of lease | ft²							19,823
Lease, base rent per year							$ 1,500,000
Increase in annual rent percentage							2.50%
Lease commencement date							Dec. 28, 2016
Original lease expiration date							Dec. 31, 2021
Accelerated lease expiration date				Feb. 28, 2020
4 Hartwell Place
Lessee Lease Description [Line Items]
Area of lease | ft²						18,707
Lease, base rent per year						$ 900,000
Increase in annual rent percentage						2.60%
Lease expiration month and year						2029-12
Lease commencement month and year						2019-07
Lessee, operating lease, existence of option to extend [true false]						true
Lessee, operating lease, option to extend							The Company has the option to extend the lease twice, each for a five-year period, on the same terms and conditions as the current lease, subject to a change in base rent based on market rates.
Lessee, operating lease, option to extend term						5 years
Tenant improvement allowance, received							$ 1,300,000
Increase in base rent	$ 100,000
Initial direct cost	0
Operating right-of-use assets obtained in exchange for operating lease liabilities	1,000,000.0
Sublease payments to be received annually	$ 1,000,000.0
Sublease income, increase in annual percentage	2.80%
Sublease commencement date	Nov. 15, 2021
Sublease income expiration date	Nov. 30, 2024
Lessee, operating sublease, existence of option to extend	true
Lessee, operating sublease, option to extend							Lonza has the option to extend the sublease term for five 12-month periods on the same terms and conditions as the current sublease, subject to an increase of 2.8% in the annual fixed rent charges.
Number of operating sublease renewal term | Renewal	5
Lessee, operating sublease, option to extend term	12 months
Percentage of annual increase in fixed rent charges	2.80%
4 Hartwell Place | Maximum
Lessee Lease Description [Line Items]
Tenant improvement allowance						$ 1,300,000
4 Hartwell Place | Letter of Credit
Lessee Lease Description [Line Items]
Security deposit							$ 400,000	400,000
35 Cambridge Park Drive
Lessee Lease Description [Line Items]
Area of lease | ft²					68,258
Lease, base rent per year					$ 4,900,000
Increase in annual rent percentage					3.00%
Lease commencement date					Mar. 26, 2019
Lease expiration month and year					2029-11
Lessee, operating lease, existence of option to extend [true false]					true
Lessee, operating lease, option to extend							The Company has the option to extend the lease for a 10-year period on the same terms and conditions as the current lease, subject to a change in base rent based on market rates.
Lessee, operating lease, option to extend term					10 years
Tenant improvement allowance					$ 12,300,000
Tenant improvement allowance, received								12,300,000
Construction oversight fee					2.00%
Area of space for sublease | ft²			23,280
Sublease payments to be received annually			$ 1,300,000
Sublease income, increase in annual percentage			3.00%
Sublease commencement date			May 18, 2020
Sublease expiration month and year		2023-05	2022-05				2023-05
Lessee, operating sublease, existence of option to extend		true	true
Lessee, operating sublease, option to extend							The sublessee had the option to extend the sublease for a one-year period on the same terms and conditions as the current sublease, subject to a change in base rent based on the greater of (i) an increase of 3% of the annual rent owed by the sublessee in year two, and (ii) market rent for the subleased premises.
Lessee, operating sublease, option to extend term		1 year	1 year
35 Cambridge Park Drive | Letter of Credit
Lessee Lease Description [Line Items]
Security deposit								$ 3,700,000	$ 3,700,000
Security deposit in connection with sublease			$ 300,000