X0306 4 2022-06-17 0 0001659352 Codiak BioSciences, Inc. CDAK 0001216078 MELAS KYRIAZI THEO C/O CODIAK BIOSCIENCES, INC. 35 CAMBRIDGEPARK DRIVE, SUITE 500 CAMBRIDGE MA 02140 1 0 0 0 Stock Option (Right to Buy) 2.83 2022-06-17 4 A 0 7500 0.00 A 2032-06-16 Common Stock 7500 7500 D Restricted Stock Units 2022-06-17 4 A 0 1500 0.00 A Common Stock 1500 1500 D This option shall vest in full upon the earlier to occur of (i) June 17, 2023 and (ii) the Issuer's next annual meeting of stockholders. Each restricted stock unit represents a contingent right to receive one share of common stock. On June 17, 2022, the reporting person was granted 1,500 restricted stock units, which shall vest in full upon the earlier to occur of (i) June 17, 2023 and (ii) the Issuer's next annual meeting of stockholders. /s/ Yalonda Howze, Attorney-in-Fact for Theo Melas-Kyriazi 2022-06-21