X0508 4 2023-12-01 0 0001659323 Iterum Therapeutics plc ITRM 0001792314 Puttagunta Sailaja C/O ITERUM THERAPEUTICS PLC FITZWILLIAM COURT, FL. 1, LEESON CLOSE DUBLIN 2 L2 IRELAND 0 1 0 0 Chief Medical Officer 0 Ordinary Shares 2023-12-01 4 A 0 8333 0.00 A 13302 D Ordinary Shares 2023-12-01 4 F 0 2933 2.12 D 10369 D Restricted Share Units 2023-12-01 4 M 0 8333 0.00 D Ordinary Shares 8333 16666 D On August 17, 2022 the Issuer effected a 1 for 15 reverse share split (the "Reverse Share Split"). The number of ordinary shares reported in this Form 4 have been adjusted to reflect the Reverse Share Split. Restricted share units ("RSUs") converted into ordinary shares on a one-for-one basis upon vesting of the RSUs. Represents the ordinary shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted RSUs. The number of RSUs reported on this Form 4 have been adjusted to reflect the Reverse Share Split. On December 1, 2021, the reporting person was granted an award of 33,333 RSUs, 25% of which vested on December 1, 2022, with a further 25% having vested on December 1, 2023. /s/ Sailaja Puttagunta 2023-12-04