X0306 4 2022-12-23 0 0001659323 Iterum Therapeutics plc ITRM 0001322927 Ahrens Brenton Karl C/O CANAAN PARTNERS 285 RIVERSIDE AVE., SUITE 250 WESTPORT CT 06880 1 0 0 0 Stock Option (Right to Buy) 0.81 2022-12-23 4 A 0 29125 0.81 A 2032-12-22 Ordinary Shares 29125 29125 D Subject to the reporting person providing continuous service to the Issuer and the other terms and conditions of the Issuer's 2018 Amended and Restated 2018 Equity Incentive Plan, as amended, the shares subject to this option shall vest in full on October 1, 2023. /s/ Brenton K. Ahrens 2022-12-28