X0306 4 2022-06-15 0 0001659323 Iterum Therapeutics plc ITRM 0001247851 HUNT RONALD C/O ITERUM THERAPEUTICS PLC FITZWILLIAM COURT, FL. 1, LEESON CLOSE DUBLIN 2 L2 IRELAND 1 0 0 0 Share Option (Right to Buy) 0.21 2022-06-15 4 A 0 647059 0.01 A 2032-06-14 Ordinary Shares 647059 647059 D Subject to the reporting person providing continuous service to the Issuer and the other terms and conditions of the Issuer's 2018 Amended and Restated 2018 Equity Incentive Plan, as amended, the shares subject to this option shall vest in full on June 15, 2023 /s/ Ronald Hunt 2022-06-17